Evaluation of circulatory microRNA-196 levels during the progression of chronic renal (kidney) disease of unknown etiology

Chronic renal disease of unknown etiology is prevalent & clinically silent until its late stages at which point patients may suffer significant irreversible damage or mortality in the lack early screening intervention. If diagnosed stage 1-3 progression chronic can be altered and complications reduced. Current diagnosing markers function, serum creatinine, blood urea uric acid have been shown to lacking high predictive value. So, there a need for next generation biomarkers suitable should not influenced by age, sex, nutritional status, current health concern. microRNAs appears very stable tissues biological fluids even under adverse conditions like extreme pH, long term room temperature storage, multiple freeze thaw cycles RNAase activity. elaborate development, maintenance function disease. miRNA-196 derived biomarker, extensively distributed renal, shows an important role diseases superior other biomarkers. The aim present study evaluate circulatory during etiology.